Depending on where you want to stay in San Diego, you can do any number of hotel arrangements, but most of them will probably involve the beach and/or a margarita.
Downtown has your usual posh big name hotels, and with the gentrification brought on by Petco Park in recent years, many new hotels in the East Village area with the Gaslamp Quarter just a short walk away. The world famous Hotel Del Coronado is on the Coronado peninsula, and demands big bucks.
Moving on up the beach North, you can stay in an old-school barracks-type motel in Point Loma and soak up a local flavor different from downtown, or up the famed beaches at Mission or Pacific beach, where the 20-somethings hang out.
675 L St
At Sixth Ave
A chain of a different class...
4500 Ocean Blvd
At Garnet Ave
Pacific Beach's Pier Hotel...
1055 Second Ave
Between Broadway and C St
Classic European Elegance...
650 F St
Between Sixth and Seventh Aves
Downtown's nightlife hotspot...
3999 Mission Blvd
4 blocks south of Grand Ave
Mission Bay's resort for all...
207 Fifth Ave
Between K and L Sts
Classic rock hotel in San Diego...
421 West B Street
San Diego's World Class W...
901 Camino Del Rio S
In the heart of Mission Valley's spectacular treats...
1 Market Pl
Seaport Village's Hyatt...
998 W Mission Bay Dr
Mission Bay's standard...
400 W Broadway
Sumptuous Urban Retreat...
1441 Quivira Rd
Iconic Mission Bay resort...
2303 Shelter Island Dr
Music and the Pacific Beach - what else is there?...
1710 West Mission Bay Drive
Infamous name on Mission Bay...
311 Island Ave
At Fourth Ave
Historic San Diego hotel...
5300 Grand Del Mar Court
European-styled influence...
1047 5th Ave
Chic lounge, bar & hotel...
435 Sixth Ave
Between J St and Island Ave
For Work or Fun...
406 Maple St
At Fourth Ave